منابع مشابه
Hypothalamic glioma masquerading as craniopharyngioma
Hypothalamic glioma account for 10-15% of supratentorial tumors in children. They usually present earlier (first 5 years of age) than craniopharyngioma. Hypothalamic glioma poses a diagnostic dilemma with craniopharyngioma and other hypothalamic region tumors, when they present with atypical clinical or imaging patterns. Neuroimaging modalities especially MRI plays a very important role in scru...
متن کاملCraniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity
PURPOSE OF REVIEW Hypothalamic alterations, pathological or treatment induced, have major impact on prognosis in craniopharyngioma patients mainly because of consequent hypothalamic obesity. Recent insight in molecular genetics, treatment strategies, risk factors and outcomes associated with hypothalamic obesity provide novel therapeutic perspectives. This review includes relevant publications ...
متن کاملHypothalamic Obesity after Craniopharyngioma: Mechanisms, Diagnosis, and Treatment
Obesity is a common complication after craniopharyngioma therapy, occurring in up to 75% of survivors. Its weight gain is unlike that of normal obesity, in that it occurs even with caloric restriction, and attempts at lifestyle modification are useless to prevent or treat the obesity. The pathogenesis of this condition involves the inability to transduce afferent hormonal signals of adiposity, ...
متن کاملHypothalamic and pituitary injury.
The hypothalamic-pituitary axis is recognized to an increasing extent as a physiological unit which influences and is influenced by endocrine and autonomic function. Anatomically, however, a clear distinction is to be drawn, with regard to both cellular and vascular anatomy, betweenthe neural (hypothalamus and neurohypophysis) and the glandular epithelial (pars distalis) components of the axis....
متن کاملHypothalamic Obesity in Craniopharyngioma Patients: Disturbed Energy Homeostasis Related to Extent of Hypothalamic Damage and Its Implication for Obesity Intervention
Hypothalamic obesity (HO) occurs in patients with tumors and lesions in the medial hypothalamic region. Hypothalamic dysfunction can lead to hyperinsulinemia and leptin resistance. This review is focused on HO caused by craniopharyngiomas (CP), which are the most common childhood brain tumors of nonglial origin. Despite excellent overall survival rates, CP patients have substantially reduced qu...
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ژورنال
عنوان ژورنال: Current Opinion in Endocrinology & Diabetes and Obesity
سال: 2016
ISSN: 1752-296X
DOI: 10.1097/med.0000000000000214